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  • Mechanisms of resistance to...
    Galletti, Giuseppe; Leach, Benjamin I; Lam, Linda; Tagawa, Scott T

    Cancer treatment reviews, 06/2017, Letnik: 57
    Journal Article

    Highlights • The optimal treatment sequencing pathway in mCRPC is yet to be fully defined. • Resistance to taxanes and AR-targeted agents complicates treatment decisions. • Multiple, heterogeneous resistance mechanisms have been proposed. • AR-V7 and ERG expression may predict resistance to AR-targeted drugs and taxanes. • Prospective trials are evaluating drug sequencing, combinations and biomarkers.