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O'Donnell, Jake S; Long, Georgina V; Scolyer, Richard A; Teng, Michele W.L; Smyth, Mark J
Cancer treatment reviews, 01/2017, Letnik: 52Journal Article
Highlights • Resistance to anti-PD1 therapy affects up to ∼60% of patients treated. • Resistance can be primary or acquired. • Tumor intrinsic mechanisms limiting tumor-specific T cells promote resistance. • Logical therapeutic combinations might prevent or treat resistant tumors.
