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Goodall, Megan; Thorburn, Andrew
Cell research, 07/2014, Letnik: 24, Številka: 7Journal Article
Macroautophagy has been implicated in numerous diseases, yet our understanding of the proteins respon- sible for the turnover of specific cargo by autophagy is limited. In a recent paper published in Nature, Mancias et al. used quantitative proteomics to identify a cohort of autophagosome- enriched proteins, one of which, nuclear receptor coactivator 4 （NCOA4） was shown to be required for the selective delivery of ferritin to the lysosome, ultimately regulating intracellular iron by autophagic turnover of ferritin, or ferritinophagy.
