E-viri
Recenzirano
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Bao, Ming; Doyle, Michael P.
Organic letters, 05/2023, Letnik: 25, Številka: 17Journal Article
A highly enantioselective preparation of substituted pyrrolidines and 1,2-oxazinanes has been achieved via stereoretentive 3 + 2/3 + 3-cycloaddition of nonracemic donor–acceptor cyclopropanes with imines, triazines, and nitrones in good to high yields with broad scope under mild reaction conditions. In comparison with the well-documented approach to donor–acceptor cyclopropane reactions using racemic cyclopropane reactants and a catalyst with chiral ligands, this report features applications of enantioenriched donor–acceptor cyclopropanes as cycloadduct reactants with achiral catalysts.
