E-viri
Recenzirano
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Paz, Weider H. P; de Oliveira, Rodolfo N; Heerdt, Gabriel; Angolini, Célio F. F; S. de Medeiros, Lívia; Silva, Valdenizia R; Santos, Luciano S; Soares, Milena B. P; Bezerra, Daniel P; Morgon, Nelson H; Almeida, Jackson R. G. S; da Silva, Felipe M. A; Costa, Emmanoel V; Koolen, Hector H. F
Journal of natural products (Washington, D.C.), 08/2019, Letnik: 82, Številka: 8Journal Article
In addition to seven known alkaloids (2, 6–11) and 1,2,4-trimethoxybenzene (1), three isoquinoline-derived alkaloids (3–5), namely, duguetinine (3), a compound based on an unprecedented oxahomoaporphine scaffold, and two new 8-oxohomoaporphine alkaloids, duguesuramine (4) and 11-methoxyduguesuramine (5), and a new asarone-derived phenylpropanoid (10) were isolated from the bark of Duguetia surinamensis. The isolation workflow was guided by HPLC-HRESIMS/MS and molecular networking-based analyses. Twenty-four known alkaloids were dereplicated from the D. surinamensis alkaloid-rich fraction network and were assigned by manual MS/MS interpretation. Their cytotoxic potential was evaluated.
