The basic motivation of this investigation is to develop an innovative mathematical model for electro-osmotic flow of Couette–Poiseuille nanofluids. The power-law model is treated as the base fluid suspended with nano-sized particles of aluminum oxide (Al2O3). The uniform speed of the upper wall in the axial path generates flow, whereas the lower wall is kept fixed. An analytic solution for nonlinear flow dynamics is obtained. The ramifications of entropy generation, magnetic field, and a constant pressure gradient are appraised. Moreover, the physical features of most noteworthy substantial factors such as the electro-osmotic parameter, magnetic parameter, power law fluid parameter, skin friction, Nusselt number, Brinkman number, volume fraction, and concentration are adequately delineated through various graphs and tables. The convergence analysis of the obtained solutions has been discussed explicitly. Recurrence formulae in each case are also presented.