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den Heijer, Casper D J; Hoebe, Christian J P A; Driessen, Johanna H M; Wolffs, Petra; van den Broek, Ingrid V F; Hoenderboom, Bernice M; Williams, Rachael; de Vries, Frank; Dukers-Muijrers, Nicole H T M
Clinical infectious diseases, 10/2019, Letnik: 69, Številka: 9Journal Article
Abstract Background We evaluated the risk of pelvic inflammatory disease (PID), ectopic pregnancy, and infertility in women with a previous Chlamydia trachomatis (CT) diagnosis compared with women who tested negative for CT and CT untested women, considering both targeted and incidental (ie, prescribed for another indication) use of CT-effective antibiotics. Methods This was a retrospective study of women aged 12–25 years at start of follow-up within the Clinical Practice Research Datalink GOLD database linked to index of multiple deprivation quintiles, 2000–2013. CT test status and antibiotic use were determined in a time-dependent manner. Risk of PID, ectopic pregnancy, or female infertility were evaluated using of Cox proportional hazard models. Results We studied 857 324 women, contributing 6 457 060 person-years. Compared with women who tested CT-negative, women who tested CT-positive had an increased risk of PID (adjusted hazard ratio aHR, 2.36; 95% confidence interval CI, 2.01–2.79), ectopic pregnancy (aHR, 1.87; 95% CI, 1.38–2.54), and infertility (aHR, 1.85; 95% CI, 1.27–2.68). The PID risk was higher for women with 2 or more positive CT tests than those with 1 positive test. PID risk increased with the number of previous antibiotic prescriptions, regardless of CT test status. Conclusions We showed an association between CT-positive tests and 3 adverse reproductive health outcomes. Moreover, this risk increased with repeat CT infections. CT-effective antibiotic use showed no decreased risks of subsequent PID regardless of CT history. Our results confirm the reproductive health burden of CT, which requires adequate public health interventions. Time-dependent analyses on a dataset including 6.5 million person-years confirms a strong relationship between Chlamydia trachomatis (CT) and pelvic inflammatory disease (PID), ectopic pregnancy, and female infertility. CT-effective antibiotic use showed no decreased PID risk in CT untested women.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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