•This is one of the first studies examining drugged driving over multiple years among US adults in the United States.•Sexual minorities are at increased risk for driving under the influence of alcohol and marijuana.•High rates of drugs, including hallucinogens, methamphetamine, and LSD were found.•Findings can inform harm reduction efforts and prevention efforts with drugged driving. Introduction: Drugged driving, the act of driving while under the influence of one or more illicit substances, remains a critical problem needing to be addressed. The present study sought to analyze risk factors associated with past-year driving under the influence of alcohol and marijuana among a national sample of U.S. adults. Method: Pooled data from the 2016–2018 National Survey on Drug Use and Health were analyzed among 124,466 adults ages 18 years or older. Results: Weighted logistic regression analyses revealed that 8.52% of adults drove under the influence of alcohol in the past year and 4.49% of adults drove under the influence of marijuana in the past year. Of concern, compared to heterosexuals, greater than 1 in 10 sexual minorities drove under the influence of alcohol in the past year. Moreover, a sizeable percentage of adults used other drugs while under the influence of alcohol including inhalants (70.3%), cocaine (68.9%), and hallucinogens (63.7%). Moreover, a great percentage of adults (53.4%) reported using methamphetamine while also under the influence of marijuana. Practical Applications: We believe our findings can inform harm reduction efforts and prevention messaging surrounding the dangers of drugged driving.