E-viri
Recenzirano
Odprti dostop
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Adinolfi, Luigi E; Nevola, Riccardo; Guerrera, Barbara; D'Alterio, Giovanni; Marrone, Aldo; Giordano, Mauro; Rinaldi, Luca
Journal of gastroenterology and hepatology, July 2018, 2018-Jul, 2018-07-00, 20180701, Letnik: 33, Številka: 7Journal Article
Background and Aim Chronic hepatitis C virus (HCV), particularly genotype 1, is associated with insulin resistance (IR) and diabetes. This study evaluated the impact of HCV clearance by all‐oral direct‐acting antiviral treatments on IR and glycemic control. Methods Included in this prospective case–control study were 133 consecutive HCV‐genotype 1 patients with advance liver fibrosis (F3–F4) without type 2 diabetes. Sixty eight were treated with direct‐acting antiviral and 65 were untreated. Liver fibrosis was assessed by transient elastography. Pre‐treatment, end‐treatment, and 3 months post‐treatment withdrawal IR homeostasis was assessed by homeostatic model assessment (HOMA)‐IR, HOMA‐S, and HOMA‐B. Results At baseline, treated, and untreated patients showed similar liver fibrosis levels, HOMA‐IR was 4.90 ± 4.62 and 4.64 ± 5.62, respectively. HOMA‐IR correlated with HCV RNA levels. At the end of treatment, all patients cleared HCV RNA, regardless of liver fibrosis and body mass index, and a reduction in HOMA‐IR at 2.42 ± 1.85 was showed (P < 0.001); in addition, increased insulin sensitivity, decreased insulin secretion, reduction of serum glucose, and insulin levels were observed. Data were confirmed 3 months after treatment withdrawal in the 65 patients who cleared HCV. No variation occurred in untreated patients. Overall, 76.5% of sustained virologic response patients showed IR improvements, of which 41.2% normalized IR. Improvement of IR was strictly associated with HCV clearance; however, patients with the highest levels of fibrosis remain associated with some degree of IR. Conclusions The data underline a role of HCV in development of IR and that viral eradication reverses IR and improves glycemic control and this could prevent IR‐related clinical manifestations and complications.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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