Melasma is a chronic hyperpigmentation disorder. Although several treatment methods are used for patients, it remains a challenging problem for physicians. Erbium-YAG laser is one of the laser treatment methods that proved its efficacy in melasma treatment. We aimed to compare the efficacy of combining the fractional Er: YAG laser and Kligman’s formula with Kligman’s formula alone in the treatment of melasma. Twenty female patients with bilateral melasma were randomly treated in a split-face controlled manner with a fractional Er: YAG laser followed by Kligman’s formula on one side and Kligman’s formula on the other side. All patients received three laser sessions with four-week intervals. The efficacy of treatments was determined through photographs, Visioface, and Melasma Area Severity Index (MASI) score, all performed at baseline and three months after the end of laser sessions. Fractional Er: YAG laser and Kligman’s formula showed a significant decrease in MASI score than Kligman’s formula alone ( P  = 0.005). There was a significant decrease in cheek Visioface score on Er: YAG laser and Kligman’s formula vs Kligman’s formula ( P  = 0.02). However, the Patient Global Assessment Scale of both sides was not statistically significant ( P  = 0.23). The combination of Fractional Er: YAG laser with Kligman’s formula is an effective treatment method for melasma.