E-viri
Recenzirano
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Mori, Masaki; Hatake, Kiyohiko; Tanaka, Masaru; Takatoku, Masaaki; Matsumoto, Yuko; Ucjhida, Mie; Kametaka, Minako; Nagai, Tadashi; Terui, Yasuhito; Tomeuka, Hiroshi; Muroi, Kazuo; Ozawa, Keiya
Leukemia & lymphoma, 2001, Letnik: 42, Številka: 3Journal Article
A 67-year-old woman was treated for acute myelogenous leukemia with trilineage dysplasia (AML-TLD) by combination chemotherapy with cytarabine, aclarubicin plus macrophage colony-stimulating factor (M-CSF) (referred to as CAM therapy). Complete remission was achieved after two courses of CAM therapy. After coculture of her bone marrow mononuclear cells with M-CSF in vitro, differentiation of leukemic cells into macrophages with apoptotis was observed. This case confirms an earlier report that an effect of M-CSF inducible by differentiation with apoptotic phenomena, against human leukemic cells was shown both in vitro and in vivo when achieving complete remission.
