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Jacoby, Elad; Bielorai, Bella; Avigdor, Abraham; Itzhaki, Orit; Hutt, Daphna; Nussboim, Vered; Meir, Amilia; Kubi, Adva; Levy, Michal; Zikich, Dragoslav; Zeltzer, Li‐at; Brezinger, Karin; Schachter, Jacob; Nagler, Arnon; Besser, Michal J.; Toren, Amos
American journal of hematology, December 2018, 2018-12-00, 20181201, Letnik: 93, Številka: 12Journal Article
Autologous CD19 chimeric‐antigen receptor (CAR) T cells demonstrated remarkable remission rates in relapsed and refractory acute lymphoblastic leukemia (R/R ALL). Here, we report results from a phase 1b/2 study of in‐house produced CD19 CAR with a CD28 costimulatory domain. Twenty‐one patients with R/R ALL were enrolled, and 20 infused. The median age was 11 years (range, 5‐48). Patients had a median of 4 prior regimens, including blinatumomab in 6 and prior stem–cell transplantation in 10. In total 8 patients had extramedullary (EM) leukemic involvement, and prior to lymphodepletion and CAR 7 had active lesions, a group underrepresented in previous trials. In vivo expansion of CAR T cells was observed in 18 patients. In total 16 patients developed cytokine release syndrome, and 11 patients developed neurotoxicity, with no toxic deaths. All responding patients were referred to an allogeneic hematopoietic stem‐cell transplantation. The remission rate was 90%, including resolution of all refractory EM sites. Four responding patients relapsed, 3 who had a PCR‐MRD positive remission at 28 days following CAR‐T cells and 1 patient 21 months after an MRD‐negative response. The estimated 1‐year event‐free survival and overall survival are 73% and 90%, respectively. Patients with R/R EM ALL may also benefit from CAR‐T cell therapy.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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