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Segura‐Amil, Alba; Nowacki, Andreas; Debove, Ines; Petermann, Katrin; Tinkhauser, Gerd; Krack, Paul; Pollo, Claudio; Nguyen, T. A. Khoa
Human brain mapping, 15 August 2023, Letnik: 44, Številka: 12Journal Article
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for advanced Parkinson's disease. Stimulation of the hyperdirect pathway (HDP) may mediate the beneficial effects, whereas stimulation of the corticospinal tract (CST) mediates capsular side effects. The study's objective was to suggest stimulation parameters based on the activation of the HDP and CST. This retrospective study included 20 Parkinson's disease patients with bilateral STN DBS. Patient‐specific whole‐brain probabilistic tractography was performed to extract the HDP and CST. Stimulation parameters from monopolar reviews were used to estimate volumes of tissue activated and to determine the streamlines of the pathways inside these volumes. The activated streamlines were related to the clinical observations. Two models were computed, one for the HDP to estimate effect thresholds and one for the CST to estimate capsular side effect thresholds. In a leave‐one‐subject‐out cross‐validation, the models were used to suggest stimulation parameters. The models indicated an activation of 50% of the HDP at effect threshold, and 4% of the CST at capsular side effect threshold. The suggestions for best and worst levels were significantly better than random suggestions. Finally, we compared the suggested stimulation thresholds with those from the monopolar reviews. The median suggestion errors for the effect threshold and side effect threshold were 1 and 1.5 mA, respectively. Our stimulation models of the HDP and CST suggested STN DBS settings. Prospective clinical studies are warranted to optimize tract‐guided DBS programming. Together with other modalities, these may allow for assisted STN DBS programming. This retrospective study included 20 Parkinson's disease patients with STN DBS. Patient‐specific tractography was performed to compute stimulation models of the hyperdirect pathway and corticospinal tract. Both models were used to suggest stimulation parameters for directional DBS leads.
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in: SICRIS
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