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Barja-Fernández, Silvia; Folgueira, Cintia; Castelao, Cecilia; Pena-León, Verónica; González-Saenz, Patricia; Vázquez-Cobela, Rocío; Aguilera, Concepción M; Gil-Campos, Mercedes; Bueno, Gloria; Gil, Ángel; Moreno, Luis A; Ruiz-Piñon, Manuel; García-Palacios, María; Casanueva, Felipe F; Diéguez, Carlos; Nogueiras, Rubén; Leis, Rosaura; Seoane, Luisa M
Nutrients, 06/2019, Letnik: 11, Številka: 6Journal Article
Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and different lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two different cohorts. In the first cohort (n = 150, age 3-17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5-18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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