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Llibre-Nieto, Gemma; Lira, Alba; Vergara, Mercedes; Solé, Cristina; Casas, Meritxell; Puig-Diví, Valentí; Solé, Gemma; Humanes, Antonia; Grau, Laia; Barradas, Josep Maria; Miquel, Mireia; Sánchez-Delgado, Jordi
Nutrients, 04/2021, Letnik: 13, Številka: 4Journal Article
Patients with cirrhosis often develop malnutrition and micronutrient deficiencies, leading to a worse prognosis and increased mortality. Our main goal was to assess the prevalence of micronutrient deficiencies in patients with decompensated cirrhosis. This was a prospective single-center study including 125 consecutive patients hospitalized for acute decompensation of cirrhosis (mostly of alcoholic etiology). A blood test including trace elements and vitamins was performed on admission. The main micronutrient deficiencies observed were vitamin D (in 94.5%), vitamin A (93.5%), vitamin B6 (60.8%) and zinc (85.6%). Patients in Child-Pugh class C had lower levels of vitamin A ( < 0.0001), vitamin E ( = 0.01) and zinc ( < 0.001), and higher levels of ferritin ( = 0.002) and vitamin B12 ( < 0.001) than those in Child-Pugh class A and B. Patients with a higher model of end-stage liver disease (MELD) score had lower levels of vitamin A ( < 0.0001), vitamin E ( < 0.001), magnesium ( = 0.01) and zinc ( = 0.001), and higher levels of ferritin ( = 0.002) and vitamin B12 ( < 0.0001). Severe hepatic insufficiency correlated with lower levels of zinc, vitamin E and vitamin A, and higher levels of vitamin B12 and ferritin.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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