We review lattice results related to pion, kaon, D- and B-meson physics with the aim of making them easily accessible to the particle-physics community. More specifically, we report on the determination of the light-quark masses, the form factor \f_+(0)\, arising in the semileptonic \K \rightarrow \pi \ transition at zero momentum transfer, as well as the decay constant ratio \f_K/f_\pi \ and its consequences for the CKM matrix elements \V_{us}\ and \V_{ud}\. Furthermore, we describe the results obtained on the lattice for some of the low-energy constants of \SU(2)_L\times SU(2)_R\ and \SU(3)_L\times SU(3)_R\ Chiral Perturbation Theory. We review the determination of the \B_K\ parameter of neutral kaon mixing as well as the additional four B parameters that arise in theories of physics beyond the Standard Model. The latter quantities are an addition compared to the previous review. For the heavy-quark sector, we provide results for \m_c\ and \m_b\ (also new compared to the previous review), as well as those for D- and B-meson-decay constants, form factors, and mixing parameters. These are the heavy-quark quantities most relevant for the determination of CKM matrix elements and the global CKM unitarity-triangle fit. Finally, we review the status of lattice determinations of the strong coupling constant \\alpha _s\.