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Bauskin, Asne R; Brown, David A; Kuffner, Tamara; Johnen, Heiko; Luo, X Wei; Hunter, Mark; Breit, Samuel N
Cancer research (Chicago, Ill.), 05/2006, Letnik: 66, Številka: 10Journal Article
Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-beta superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion, processing, and latent storage suggest a complex, dynamic variability in MIC-1 bioavailability in the tumor microenvironment, potentially modulating tumor progression and invasiveness.
