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Near, Aimee M; Wu, Anna H; Templeman, Claire; Van Den Berg, David J; Doherty, Jennifer A; Rossing, Mary Anne; Goode, Ellen L; Cunningham, Julie M; Vierkant, Robert A; Fridley, Brooke L; Chenevix-Trench, Georgia; Webb, Penelope M; Kjær, Susanne Krüger; Hogdall, Estrid; Gayther, Simon A; Ramus, Susan J; Menon, Usha; Gentry-Maharaj, Aleksandra; Schildkraut, Joellen M; Moorman, Patricia G; Palmieri, Rachel T; Ness, Roberta B; Moysich, Kirsten; Cramer, Daniel W; Terry, Kathryn L; Vitonis, Allison F; Pike, Malcolm C; Berchuck, Andrew; Pearce, Celeste Leigh
Fertility and sterility, 01/2011, Letnik: 95, Številka: 1Journal Article
OBJECTIVE: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. DESIGN: Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies. SETTING: An international ovarian cancer consortium including studies from Australia, Europe, and the United States. PATIENT(S): Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Genotypes for the +331C/T single nucleotide polymorphism and PROGINS allele and a history of endometriosis. RESULT(S): The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (odds ratio = 0.65; 95% confidence interval: 0.43–0.98), whereas there was no association between the PROGINS allele and endometriosis (odds ratio = 0.94, 95% confidence interval 0.76–1.16). CONCLUSION(S): Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced progesterone (P) receptor A to P receptor B ratio, and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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