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Jin, Zhenming; Zhao, Yao; Sun, Yuan; Zhang, Bing; Wang, Haofeng; Wu, Yan; Zhu, Yan; Zhu, Chen; Hu, Tianyu; Du, Xiaoyu; Duan, Yinkai; Yu, Jing; Yang, Xiaobao; Yang, Xiuna; Yang, Kailin; Liu, Xiang; Guddat, Luke W; Xiao, Gengfu; Zhang, Leike; Yang, Haitao; Rao, Zihe
Nature structural & molecular biology, 06/2020, Letnik: 27, Številka: 6Journal Article
The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (M ). Here, the X-ray crystal structure of M in complex with carmofur reveals that the carbonyl reactive group of carmofur is covalently bound to catalytic Cys145, whereas its fatty acid tail occupies the hydrophobic S2 subsite. Carmofur inhibits viral replication in cells (EC = 24.30 μM) and is a promising lead compound to develop new antiviral treatment for COVID-19.
