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  • Shedding Light on ecDNA Beh...
    Henssen, Anton G

    Cancer discovery, 02/2022, Letnik: 12, Številka: 2
    Journal Article

    Extrachromosomal oncogene amplification on extrachromosomal DNA (ecDNA) has emerged as a hallmark of many cancers. In this issue, Yi and colleagues developed a CRISPR-based method for imaging ecDNA in live cells, termed ecTag. Using ecTag, the authors reveal important features of ecDNA in cancer cells such as their random mitotic segregation and clustering into transcriptionally active hubs after mitosis. .