E-viri
Recenzirano
Odprti dostop
-
Iglesias, Pedro; Nocete, Ignacio; Moure Rodríguez, María Dolores; Venegas-Moreno, Eva; Ares, Jessica; Biagetti, Betina; Rodríguez Berrocal, Victor; Guerrero-Pérez, Fernando; Vicente, Almudena; Villar-Taibo, Rocío; Cordido, Fernando; Paja, Miguel; Glerean, Mariela; González Rivera, Natividad; Dios Fuentes, Elena; Blanco, Concepción; Alvaréz-Escolá, Cristina; Martín, Tomás; Webb, Susan M; Bernabéu, Ignacio; Villabona, Carles; Soto-Moreno, Alfonso; Gaztambide, Sonia; Díez, Juan J
Neuroendocrinology, 09/2021, Letnik: 111, Številka: 10Journal Article
Craniopharyngioma (CP) is a rare tumor in the elderly whose clinical features and prognosis are not well known in this population. To evaluate the clinicopathological features and therapeutic outcomes of CP diagnosed in the elderly. This was a retrospective, multicenter, national study of CP patients diagnosed over the age of 65 years and surgically treated. From a total of 384 adult CP patients, we selected 53 (13.8%) patients (27 women 50.9%, mean age 72.3 ± 5.1 years range 65-83 years) diagnosed after the age of 65 years. The most common clinical symptoms were visual field defects (71.2%) followed by headache (45.3%). The maximum tumor diameter was 2.9 ± 1.1 cm. In most patients, the tumor was suprasellar (96.2%) and mixed (solid-cystic) (58.5%). The surgical approach most commonly used was transcranial surgery (52.8%), and more than half of the patients (54.7%) underwent subtotal resection (STR). Adamantinomatous CP and papillary CP were present in 51 and 45.1%, respectively, with mixed forms in the remaining. Surgery was accompanied by an improvement in visual field defects and in headaches; however, pituitary hormonal hypofunction increased, mainly at the expense of an increase in the prevalence of diabetes insipidus (DI) (from 3.9 to 69.2%). Near-total resection (NTR) was associated with a higher prevalence of DI compared with subtotal resection (87.5 vs. 53.6%, p = 0.008). Patients were followed for 46.7 ± 40.8 months. The mortality rate was 39.6% with a median survival time of 88 (95% CI: 57-118) months. DI at last visit was associated with a lower survival. CP diagnosed in the elderly shows a similar distribution by sex and histologic forms than that diagnosed at younger ages. At presentation, visual field alterations and headaches are the main clinical symptoms which improve substantially with surgery. However, surgery, mainly NTR, is accompanied by worsening of pituitary function, especially DI, which seems to be a predictor of mortality in this population.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.