Pegylated IFN- alpha 2a combined to imatinib mesylate 600 mg daily can induce complete cytogenetic and molecular responses in a subset of chronic phase CML patients refractory to IFN alone or to imatinib 600 mg daily alone

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$Pegylated IFN- alpha 2a combined to imatinib mesylate 600 mg daily can induce complete cytogenetic and molecular responses in a subset of chronic phase CML patients refractory to IFN alone or to imatinib 600 mg daily alone$

Pegylated IFN- alpha 2a combined to imatinib mesylate 600 mg daily can induce complete cytogenetic and molecular responses in a subset of chronic phase CML patients refractory to IFN alone or to imatinib 600 mg daily alone

Nicolini, Franck E; Hayette, Sandrine; Legros, Laurence; Rousselot, Philippe; Maloisel, Frederic; Tulliez, Michel; Guerci, Agnes; Charbonnier, Aude; Prebet, Thomas; Rigal-Huguet, Francoise; Chabane, Kaddour; Magaud, Jean-Pierre; Paillet, Carole; Pivot, Christine; Michallet, Mauricette

Leukemia research, 01/2011, Letnik: 35, Številka: 1

Journal Article

This phase I/II study was designed to demonstrate the tolerance and the efficacy of a combination of pegylated interferon- alpha 2a to Imatinib mesylate (IM) 600 mg daily in cytogenetically IM-resistant but in CHR chronic phase CML patients. The combination was generally well tolerated in the 15 evaluable patients. A significant reduction of the Ph1 super(+) BM metaphases was observed in these poor prognosis patients, with 2 long-term CCyR including 2 MMR. After a median follow-up of 43 months, 93% of patients are alive. The addition of PegIFN alpha 2a to IM600 is feasible, and able to overcome resistance within this context.

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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.

Leto	Faktor vpliva		Izdaja		Kategorija		Razvrstitev
Leto	JCR	SNIP	JCR	SNIP	JCR	SNIP	JCR	SNIP

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