Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A 2 Type X (sPLA 2 -X) Inhibitors

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Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A 2 Type X (sPLA 2 -X) Inhibitors

Knerr, Laurent; Giordanetto, Fabrizio; Nordberg, Peter; Pettersen, Daniel; Selmi, Nidhal; Beisel, Hans-Georg; de la Motte, Hannah; Olsson, Thomas; Perkins, Tim D J; Herslöf, Margareta; Månsson, Åsa; Dahlström, Mikael; Starke, Ingemar; Broddefalk, Johan; Saarinen, Gabrielle; Klingegård, Fredrik; Hurt-Camejo, Eva; Rosengren, Birgitta; Brengdahl, Johan; Jansen, Frank; Rohman, Mattias; Sandmark, Jenny; Hallberg, Kenth; Åkerud, Tomas; Roth, Robert G; Ahlqvist, Marie

ACS medicinal chemistry letters, 2018-Jul-12, 2018-07-12, Letnik: 9, Številka: 7

Journal Article

In order to assess the potential of sPLA -X as a therapeutic target for atherosclerosis, novel sPLA inhibitors with improved type X selectivity are required. To achieve the objective of identifying such compounds, we embarked on a lead generation effort that resulted in the identification of a novel series of indole-2-carboxamides as selective sPLA2-X inhibitors with excellent potential for further optimization.

Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.

Leto	Faktor vpliva		Izdaja		Kategorija		Razvrstitev
Leto	JCR	SNIP	JCR	SNIP	JCR	SNIP	JCR	SNIP

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