This study was conducted to evaluate the growth response of three leafy vegetables (Celosia argentea, Amaranthus cruentus and Amaranthus hypochodriacus) to the leaf extract of Vitellaria paradoxa. Forty-five (45) experimental plastic containers were filled with 5 kg of loamy soil each and randomly allocated to the following regimes: control, 20 g, 40 g, 60 g and 80 g of powdered leaves of V. paradoxa, in three (3) replicates for each test crop respectively. It was observed that the response of the three leafy vegetables, grown within different composition of V. paradoxa leaves, are concentration dependent with respect to the studied growth parameters (plant height, leaf number, leaf area, stem girth). This indicated that V. paradoxa has allelopathic potential on the studied vegetables and therefore it could be used for natural weed control.