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Falcó, Vicenç; Olmo, Montserrat; del Saz, Sara Villar; Guelar, Ana; Santos, José R; Gutiérrez, Mar; Colomer, Daniel; Deig, Elisabet; Mateo, Gracia; Montero, Milagro; Pedrol, Enric; Podzamczer, Daniel; Domingo, Pere; Llibre, Josep M
Journal of acquired immune deficiency syndromes (1999), 09/2008, Letnik: 49, Številka: 1Journal Article
The aim of this study was to analyze the incidence of new cases, survival of HIV-1-infected patients with progressive multifocal leukoencephalopathy (PML), and the characteristics of PML-associated immune reconstitution inflammatory syndrome (IRIS). Multicenter observational cohort study of all HIV-1-infected patients newly diagnosed of PML in 7 hospitals in Barcelona (Spain) from 2002 to 2006. The annual incidence of PML was calculated. Survival was estimated using the Kaplan-Meier method. IRIS was defined as new onset or rapid worsening of PML shortly after initiation of highly active antiretroviral therapy together with a decline in HIV-1 viral load and rising of CD4 lymphocytes. Sixty-one new cases of PML were diagnosed. The mean survival time was 15 months 95% confidence interval (CI), 11 to 19. The Kaplan-Meier estimates of the probability of survival were 47.7% (95% CI, 35 to 59) at 6 months, 38.6% (95% CI, 25 to 51) at 12 months, 35.1% (95% CI, 22 to 48) at 24 months, and 25.1% (95% CI, 10 to 40) at 36 months. IRIS was diagnosed in 14 (23%) cases. Mortality was similar in patients with and without IRIS. PML continues to be one of the deadliest opportunistic infections in acquired immunodeficiency syndrome patients. The development of PML-associated IRIS has no influence on prognosis.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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