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Kim, Jihye; Bury, Matthew I; Kwon, Kyeongha; Yoo, Jae-Young; Halstead, Nadia V; Shin, Hee-Sup; Li, Shupeng; Won, Sang Min; Seo, Min-Ho; Wu, Yunyun; Park, Do Yun; Kini, Mitali; Kwak, Jean Won; Madhvapathy, Surabhi R; Ciatti, Joanna L; Lee, Jae Hee; Kim, Suyeon; Ryu, Hanjun; Yamagishi, Kento; Yoon, Hong-Joon; Kwak, Sung Soo; Kim, Bosung; Huang, Yonggang; Halliday, Lisa C; Cheng, Earl Y; Ameer, Guillermo A; Sharma, Arun K; Rogers, John A
Proceedings of the National Academy of Sciences - PNAS, 2024-Apr-02, 2024-04-02, 20240402, Letnik: 121, Številka: 14Journal Article
Partial cystectomy procedures for urinary bladder-related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient-friendly, they exhibit user-to-user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter-associated urinary tract infections, which can progress to ascending pyelonephritis due to prolonged lower tract manipulation in high-risk patients. Here, we introduce a fully bladder-implantable platform that allows for continuous, real-time measurements of changes in mechanical strain associated with bladder filling and emptying via wireless telemetry, including a wireless bioresorbable strain gauge validated in a benchtop partial cystectomy model. We demonstrate that this system can reproducibly measure real-time changes in a rodent model up to 30 d postimplantation with minimal foreign body response. Studies in a nonhuman primate partial cystectomy model demonstrate concordance of pressure measurements up to 8 wk compared with traditional UDS. These results suggest that our system can be used as a suitable alternative to UDS for long-term postoperative bladder recovery monitoring.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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