We present a new characterization of the relations between star-formation rate, stellar mass and molecular gas mass surface densities at different spatial scales across galaxies (from galaxy wide to kpc-scales). To do so we make use of the largest sample combining spatially-resolved spectroscopic information with CO observations, provided by the EDGE-CALIFA survey, together with new single dish CO observations obtained by APEX. We show that those relations are the same at the different explored scales, sharing the same distributions for the explored data, with similar slope, intercept and scatter (when characterized by a simple power-law). From this analysis, we propose that these relations are the projection of a single relation between the three properties that follows a distribution well described by a line in the three-dimension parameter space. Finally, we show that observed secondary relations between the residuals and the considered parameters are fully explained by the correlation between the uncertainties, and therefore have no physical origin. We discuss these results in the context of the hypothesis of self-regulation of the star-formation process.