A study of prompt Ξ + 𝑐 production in proton-lead collisions is performed with the LHCb experiment at a center-of-mass energy per nucleon pair of 8.16 TeV in 2016 in 𝑝⁢Pb and Pb⁢𝑝 collisions with an estimated integrated luminosity of approximately 12.5 and 17.4 nb −1 , respectively. The Ξ + 𝑐 production cross section, as well as the Ξ + 𝑐 to Λ + 𝑐 production cross-section ratio, are measured as a function of the transverse momentum and rapidity and compared to the latest theory predictions. The forward-backward asymmetry is also measured as a function of the Ξ + 𝑐 transverse momentum. The results provide strong constraints on theoretical calculation and are a unique input for hadronization studies in different collision systems.