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Benjamini, Ohad; Fried, Shalev; Shouval, Roni; Flynn, Jessica R.; Beyar-Katz, Ofrat; Leslie, Lori A; Zucherman, Tsilla; Yerushalmi, Ronit; Shem-Tov, Noga; Palomba, Maria Lia; Danylesko, Ivetta; Sdayoor, Inbal; Malka, Hila; Itzhaki, Orit; Suh, Hyung; Devlin, Sean M.; Marcus, Ronit; Dahi, Parastoo B; Jacoby, Elad; Shah, Gunjan L; Sauter, Craig S; Ip, Andrew; Perales, Miguel-Angel; Nagler, Arnon; Shimoni, Avichai; Scordo, Michael; Avigdor, Abraham
Haematologica (Roma), 06/2024, Letnik: 999, Številka: 1Journal Article
The activity of anti-CD19 CAR T cell therapy in chronic lymphocytic leukemia (CLL) with Richter's transformation (RT) to aggressive large B cell lymphoma (LBCL) is largely unknown. In a multicenter retrospective study, we report the safety and efficacy of CAR T cell therapy in patients with RT (n=30) compared to patients with aggressive B cell lymphoma (n=283) and patients with transformed indolent Non-Hodgkins Lymphoma (iNHL) (n=141) between April 2016 and January 2023. Two-thirds of patients received prior therapy for CLL before RT and 89% of them received B-cell receptor and B-cell lymphoma 2 (BCL-2) inhibitors. Toxicities of CAR T cell therapy in RT were similar to other lymphomas, with no fatalities related to cytokine release syndrome or immune effector-cell associated neurotoxicity synderome. The 100-day overall response rate and complete response rates in patients with RT were 57% and 47%, respectively. With a median follow up of 19 months, the median overall survival (OS) was 9.9 months in patients with RT compared to 18 months in de-novo LBCL and not reached in patients with transformed iNHL. The OS at 12 months was 45% in patients with RT compared with 62% and 75% in patients with de novo LBCL and transformed iNHL, respectively. In a multivariate analysis, worse OS was associated with RT histology, elevated LDH, and more prior lines of therapy. CAR T cell therapy can salvage a proportion of patients with CLL and RT exposed to prior targeted agents; however, efficacy in RT is inferior compared to de novo LBCL and transformed iNHL
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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