E-viri
Recenzirano
Odprti dostop
-
Huang, Jian; Qian, Zhaoyang; Gong, Yuhua; Wang, Yanzhou; Guan, Yanfang; Han, Yingxin; Yi, Xin; Huang, Wanqiu; Ji, Liyan; Xu, Jiajia; Su, Mengyuan; Yuan, Qing; Cui, Shujian; Zhang, Jinling; Bao, Chaohui; Liu, Weilong; Chen, Xi; Zhang, Ming; Gao, Xiaohuan; Wu, Renhua; Zhang, Yinxin; Xu, Huicheng; Zhu, Shida; Zhu, Hongmei; Yang, Ling; Xu, Xun; Zhou, Pingyu; Liang, Zhiqing
Journal of medical genetics, 03/2019, Letnik: 56, Številka: 3Journal Article
To better understand the pathogenesis of cervical cancer (CC), we systematically analysed the genomic variation and human papillomavirus (HPV) integration profiles of cervical intraepithelial neoplasia (CIN) and CC. We performed whole-genome sequencing or whole-exome sequencing of 102 tumour-normal pairs and human papillomavirus probe capture sequencing of 45 CCs, 44 CIN samples and 25 normal cervical samples, and constructed strict integrated workflow of genomic analysis. Mutational analysis identified eight significantly mutated genes in CC including four genes ( , , and ), which have not previously been reported in CC. Targetable alterations were identified in 55.9% of patients. In addition, HPV integration breakpoints occurred in 97.8% of the CC samples, 70.5% of the CIN samples and 42.8% of the normal cervical samples with HPV infection. Integrations of high-risk HPV strains in CCs, including HPV16, 18, 33 and 58, also occurred in the CIN samples. Moreover, gene mutations were detected in 52% of the CIN specimens, and 54.8% of these mutations occurred in genes that also mutated in CCs. Our results lay the foundation for a deep understanding of the molecular mechanisms and finding new diagnostic and therapeutic targets of CC.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.