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LEE, H.; CHO, E. J.; SON, H.; KIM, H.O.; HONG, Y.; YANG, S. H.; YOON, S. J.; LEE, J. H.; SHIM, J. K.; CHANG, J. H.; KANG, S.G.; HUH, Y. M.
Digest Journal of Nanomaterials and Biostructures, 07/2020, Letnik: 15, Številka: 3Journal Article
It is very desirable to design dual-mode nanocomposites for diagnostic applications via flexible strategies. Herein, we proposed to synthesize one type of multifunctional magnetic resonance (MR)/optic nanocomposites based on manganese ferrite magnetic nanoparticles (MFNPs) modified by fluorescent podoplanin (PDPN) antibodies. MFNPs were synthesized using a thermal decomposition method and were modified by the fluorescent PDPN antibodies on their surfaces. The fluorescent PDPN antibody-conjugated MFNPs enabled strong MR imaging and fluorescence imaging due to the antibodies that targeted brain tumors. These results demonstrate that MR/optic nanocomposites have potential as precision diagnostic systems for brain cancer.
