The effects of the use of antibiotics and garlic powder in the nutrition of weaning piglets were compared. The trial included 120 weaned piglets of the same genotype (Large White) distributed in three feeding treatments. In the first study period (day 27-56), a feed mixture with 20% protein was used, while in the second period (day 57-84), a mixture with 18% protein. The control group was fed with mixtures containing antibiotics in the amount of 0.2%, while the two experimental groups were fed with mixtures containing fermented garlic powder (FGP) in the concentration of 0.05% and 0.2%. The obtained results showed that the use of FGP, instead of antibiotics, resulted in better gain in second trial group, and also better feed conversion ratio, in both trial groups by 3.84% and 6.93% respectively, during the entire research period.