Air pollution is one of the major environmental problems, especially in industrial and highly populated areas. Remote sensing image is a rich source of information with many uses. This paper is focused on estimation of air pollutants using Landsat-5 TM and Landsat-8 OLI satellite images. Particulate Matter with particle size less than 10 microns (PM10) is estimated for the study area of Principado de Asturias (Spain). When a satellite records the radiance of the surface received at sensor, does not represent the true radiance of the surface. A noise caused by Aerosol and Particulate Matters attenuate that radiance. In many applications of remote sensing, that noise called path radiance is removed during pre-processing. Instead, path radiance was used to estimate the PM10 concentration in the air. A relationship between the path radiance and PM10 measurements from ground stations has been established using Random Forest (RF) algorithm and a PM10 map was generated for the study area. The results show that PM10 estimation through satellite image is an efficient technique and it is suitable for local and regional studies.