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Cao, Zhusong; Li, Jianye; Sun, Youwen; Zhang, Hanwen; Mo, Xueling; Cao, Xin; Zhang, Guozhu
Chemical science (Cambridge), 02/2021, Letnik: 12, Številka: 13Journal Article
A method for remote radical C-H alkynylation and amination of diverse aliphatic alcohols has been developed. The reaction features a copper nucleophile complex formed in situ as a photocatalyst, which reduces the silicon-tethered aliphatic iodide to an alkyl radical to initiate 1, n -hydrogen atom transfer. Unactivated secondary and tertiary C-H bonds at β, γ, and δ positions can be functionalized in a predictable manner. Remote C−H alkynylation and amination of aliphatic alcohols.
