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Delabie, Pierre; Baudin, Éric; Hentic, Olivia; Afchain, Pauline; Rusu, Timofei; Montravers, Françoise
Medicine (Baltimore), 2022-Nov-25, 2022-11-25, 20221125, Letnik: 101, Številka: 47Journal Article
The main purpose of this retrospective study was to determine the diagnostic performance of 68GaGa-DOTA-D-Phe1-Try3-octreotide(DOTA-TOC) positron emission tomography/computed tomography (PET/CT) in patients with well-differentiated colorectal Neuroendocrine Tumours (NETs) originating from the hindgut. The other aims were to assess the impact of the examination on patient management and to analyze the results of 2-18FFDG and/or 6-18FFDOPA PET/CT when they were performed. 68GaGa-DOTA-TOC PET/CT and clinical data from 30 patients with biopsy-proven well-differentiated NETs originating from the hindgut were retrospectively reviewed and analyzed by comparing the 68GaGa-DOTA-TOC PET/CT findings with pathological and/or follow-up data. We also compared the 68GaGa-DOTA-TOC PET/CT results with 2-18FFDG and/or 6-18FFDOPA PET/CT results in 6 patients. The impact on management was determined in hindsight by comparing the patient management decided before and after the TEP examination based on data from multidisciplinary team meetings. On a patient basis, 68GaGa-DOTA-TOC PET/CT was accurate in 30 of the 30 examinations. 68GaGa-DOTA-TOC PET/CT correctly identified the primary tumor in all patients with primary tumors not resected before the examination and allowed the detection of unexpected distant metastases in 36% of the patients referred for initial staging. 68GaGa-DOTA-TOC PET/CT findings affected patient management in 57% of cases with generally major intermodality changes. Intraindividual comparison of the results of the different PET radiopharmaceuticals showed a clear superiority of 68GaGa-DOTA-TOC PET/CT considering both the number of lesions and the intensity of uptake. 68GaGa-DOTA-TOC PET/CT is an accurate imaging modality for the assessment of well-differentiated colorectal NETs that highly impact patient management. Thus, we suggest that 68GaGa-DOTA-TOC PET/CT be employed as a first choice for the assessment of these tumors in nuclear medicine.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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