Objective: The objective of this retrospective study is to evaluate the usefulness of the ACBI/CMC EQAS program in the overall performance of Indian Laboratories as well as individual labs in different categories over the years. It is the journey of our National EQAS over the past decade. Method: The awareness of the Indian labs towards quality assurance is evaluated based on the number of participants, the response in submitting results, annual evaluation and the trend in methods selection. Similarly few labs form each category such as lab size (number of parameters done), type (public/private) and few labs at random were selected and their performance is evaluated over the past 10 years. Results: The awareness of Quality assurance in India has tremendously increased and is reflected by a 100% increase in the number of participants over the past ten years. The randomly selected labs showed decreased OMVIS which is indirectly proportional to their performance. Conclusion: It was during this past 10 years, lot of changes took place in the ACBI/CMC EQAS, i.e., change over form bovine sera to human sera, liquid samples to lyophilised samples, introducing immunoassay program etc. This study shows how the Indian laboratories have improved their performance as well as their awareness towards the QA-concept. It is very encouraging to note that the concept of EQAS is well accepted and appreciated by majority of laboratories and thus paving the way towards international standards.