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Jianu, Elena-Mihaela; Pop, Raluca Maria; Gherman, Luciana Mădălina; Ranga, Floricuța; Levai, Antonia-Mihaela; Rus, Vasile; Bolboacă, Sorana D; Ștefan, Roxana-Adelina; Onofrei, Mădălin Mihai; Nati, Ionel-Daniel; Stoia, Ioana Alexandra; Ștefan, Paul-Andrei; Mihu, Carina; Mihu, Carmen Mihaela
Molecules (Basel, Switzerland), 02/2024, Letnik: 29, Številka: 4Journal Article
Endometriosis is a common gynecological condition with a complex physio-pathological background. This study aimed to assess the role of Rubus idaeus leaf extract (RiDE) as a potential therapeutic agent in reducing the size of the endometriotic lesions and modulate the plasma expression of MMP-2, MMP-9, and TGF-β1. The endometriotic lesions were induced in a rat model by the autologous transplant of endometrium. Thirty-six female rats, Wistar breed, with induced endometriosis, were divided into four groups and underwent treatment for 28 days. The CTRL group received 0.5 mL/day of the vehicle; the DG group received 1 mg/kg b.w./day dienogest; the RiDG group received 0.25 mL/kg b.w./day RiDE and the D+RiDG group received 1 mg/kg b.w./day dienogest and 0.25 mL/kg b.w./day RiDE, respectively. Rats’ weight, endometriotic lesion diameter and grade, and plasma levels of MMP-2, MMP-9, and TGF-β1 were assessed before and after treatment. The administration of RiDE in association with dienogest vs. dienogest determined a lower weight gain and a reduction in diameter of the endometriotic lesions. RiDE administration restored MMP2 and MMP9 plasma levels to initial conditions. Rubus idaeus extract may help in reducing dienogest-associated weight gain, lower the size of endometriotic lesions, and have anti-inflammatory effects through MMP2 and MMP9 reduction.
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