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Herath, Kithsiri B; Zhang, Chaowei; Jayasuriya, Hiranthi; Ondeyka, John G; Zink, Deborah L; Burgess, Bruce; Wang, Jun; Singh, Sheo B
Organic letters, 05/2008, Letnik: 10, Številka: 9Journal Article
Platensimycin and platencin are novel natural product antibiotics that inhibit bacterial growth by inhibiting condensing enzymes FabF and FabF/FabH of fatty acid biosynthesis pathways, respectively. Continued search for the natural congeners of these compounds led to the isolation of platensic acid, the free C-17 tetracyclic enoic acid, and platensimide A, a 2,4-diaminobutyric acid amide derivative. Isolation, structure, semisynthesis, and activity of these compounds are described.
