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Yamauchi, Ryo; Takeyama, Yasuaki; Takata, Kazuhide; Fukunaga, Atsushi; Sakurai, Kunitoshi; Tanaka, Takashi; Fukuda, Hiromi; Fukuda, Sho; Kunimoto, Hideo; Umeda, Kaoru; Morihara, Daisuke; Yokoyama, Keiji; Irie, Makoto; Shakado, Satoshi; Sakisaka, Shotaro; Hirai, Fumihito
Internal Medicine, 2020Journal Article
An 88-year-old man was admitted for elevated liver enzyme levels. Nine years earlier, the patient had been diagnosed with diffuse large B-cell lymphoma (DLBCL) and undergone rituximab, cyclophosphamide, doxorubicin hydrochloride, oncovin, prednisone (R-CHOP) therapy. This patient previously had had a hepatitis B virus (HBV) infection before chemotherapy. After the chemotherapy, he was administered an LHRH agonist for prostate cancer. We diagnosed him with HBV reactivation because of positive serum HBV-DNA. HBV reactivation can occur a long time after chemotherapy, particularly if another treatment with immunity-altering drugs is added. In such cases, additional surveillance may be required to detect HBV reactivation.
