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García-García, Patricia; Ladépêche, Arnaud; Halder, Rajkumar; List, Benjamin
Angewandte Chemie (International ed.), June 9, 2008, Letnik: 47, Številka: 25Journal Article
Acetaldehyde, now a big contender: A silyl prolinol derivative was found to catalyze the first Michael addition of acetaldehyde with both aromatic and aliphatic nitroolefins in excellent enantioselectivities (see scheme, TMS=trimethylsilyl). The utility of the reaction is illustrated in the synthesis of three current pharmaceuticals and in the synthesis of an enantiopure 3‐monosubstituted pyrrolidine.
