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Batalla, Alberto; Alvarez, Ruth; Reguero, Julián R; González, Pelayo; Alvarez, Victoria; Cubero, Gustavo I; Cortina, Arturo; Coto, Eliecer
International journal of cardiology, 09/2001, Letnik: 80, Številka: 2Journal Article
In order to determine the role of two polymorphisms in the factor VII gene (R353Q and intron 7 hypervariable region) in the susceptibility to develop early myocardial infarction, a total of 175 patients with acute myocardial infarction aged 50 years or less (mean age 41±7 years) and 200 controls (average age 42±6) without cardiovascular disease were genotyped for these polymorphisms. Gene and genotype frequencies did not differ between patients and controls. Although the 353-QQ genotype was at a higher frequency among controls (4%) compared to patients (1%), the difference did not reach statistical significance. Carriers of the H7-allele (intron 7 polymorphism) were at a slightly higher frequency among patients (51 vs. 43%; P=0.19; OR=1.36; 95% CI=1.09–1.70). Our data suggest a lack of association between both polymorphisms in the factor VII gene and early myocardial infarction in our population.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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