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Matsumoto, Akira; Ishii, Takehiko; Nishida, Junko; Matsumoto, Hiroko; Kataoka, Kazunori; Miyahara, Yuji
Angewandte Chemie (International ed.), February 27, 2012, Letnik: 51, Številka: 9Journal Article
Protein‐free: A hydrogel containing phenylboronate was optimized so as to undergo rapid glucose‐dependent changes in the state of hydration under physiological aqueous conditions. A localized dehydration of the gel surface to form a “skin layer” enabled control of the release of insulin from the gel. This dehydration is induced by fluctuations in the glucose concentration in the range between normo‐ and hyperglycemia.
