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  • Identification of N,N-Disub...
    Chan, Laval; Reddy, T. Jagadeeswar; Proulx, Mélanie; Das, Sanjoy K; Pereira, Oswy; Wang, Wuyi; Siddiqui, Arshad; Yannopoulos, Constantin G; Poisson, Carl; Turcotte, Nathalie; Drouin, Alexandre; Alaoui-Ismaili, M. Hicham; Bethell, Richard; Hamel, Martine; L'Heureux, Lucille; Bilimoria, Darius; Nguyen-Ba, Nghe

    Journal of medicinal chemistry, 04/2003, Letnik: 46, Številka: 8
    Journal Article

    The HCV NS5B RNA dependent RNA polymerase plays an essential role in viral replication. The discovery of a novel class of inhibitors based on an N,N-disubstituted phenylalanine scaffold and structure−activity relationships studies to improve potency are described.