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Heidelberg, John F; Seshadri, Rekha; Haveman, Shelley A; Hemme, Christopher L; Paulsen, Ian T; Kolonay, James F; Eisen, Jonathan A; Ward, Naomi; Methe, Barbara; Brinkac, Lauren M; Daugherty, Sean C; Deboy, Robert T; Dodson, Robert J; Durkin, A Scott; Madupu, Ramana; Nelson, William C; Sullivan, Steven A; Fouts, Derrick; Haft, Daniel H; Selengut, Jeremy; Peterson, Jeremy D; Davidsen, Tanja M; Zafar, Nikhat; Zhou, Liwei; Radune, Diana; Dimitrov, George; Hance, Mark; Tran, Kevin; Khouri, Hoda; Gill, John; Utterback, Terry R; Feldblyum, Tamara V; Wall, Judy D; Voordouw, Gerrit; Fraser, Claire M
Nature biotechnology, 05/2004, Letnik: 22, Številka: 5Journal Article
Desulfovibrio vulgaris Hildenborough is a model organism for studying the energy metabolism of sulfate-reducing bacteria (SRB) and for understanding the economic impacts of SRB, including biocorrosion of metal infrastructure and bioremediation of toxic metal ions. The 3,570,858 base pair (bp) genome sequence reveals a network of novel c-type cytochromes, connecting multiple periplasmic hydrogenases and formate dehydrogenases, as a key feature of its energy metabolism. The relative arrangement of genes encoding enzymes for energy transduction, together with inferred cellular location of the enzymes, provides a basis for proposing an expansion to the 'hydrogen-cycling' model for increasing energy efficiency in this bacterium. Plasmid-encoded functions include modification of cell surface components, nitrogen fixation and a type-III protein secretion system. This genome sequence represents a substantial step toward the elucidation of pathways for reduction (and bioremediation) of pollutants such as uranium and chromium and offers a new starting point for defining this organism's complex anaerobic respiration.
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Vir: Osebne bibliografije
in: SICRIS
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