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Ezine, Sophie; García-Ojeda, Marcos E; Pasqualetto, Valerie; Guy-Grand, Delphine; Di Santo, James P; Rocha, Benedita; Vosshenrich, Christian A J; Samson-Villéger, Sandrine I; Goff, Odile Richard-Le; Enault, Laurence; Cumano, Ana; Rogge, Lars; Corcuff, Erwan
Nature Immunology, 11/2006, Letnik: 7, Številka: 11Journal Article
Natural killer (NK) cell development is thought to occur in the bone marrow. Here we identify the transcription factor GATA-3 and CD127 (IL-7R alpha) as molecular markers of a pathway of mouse NK cell development that originates in the thymus. Thymus-derived CD127+ NK cells repopulated peripheral lymphoid organs, and their homeostasis was strictly dependent on GATA-3 and interleukin 7. The CD127+ NK cells had a distinct phenotype (CD11b(lo) CD16- CD69(hi) Ly49(lo)) and unusual functional attributes, including reduced cytotoxicity but considerable cytokine production. Those characteristics are reminiscent of human CD56(hi) CD16- NK cells, which we found expressed CD127 and had more GATA-3 expression than human CD56+ CD16+ NK cells. We propose that bone marrow and thymic NK cell pathways generate distinct mouse NK cells with properties similar to those of the two human CD56 NK cell subsets.
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