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Liu, Xiaoxiang; Wang, Tao; Xu, Qingge; Ma, Chunrong; Cook, James M
Tetrahedron letters, 08/2000, Letnik: 41, Številka: 33Journal Article
The enantiomer of affinisine has been synthesized (from l-tryptophan) with 100% diastereoselectivity via the asymmetric Pictet–Spengler reaction coupled with a Pd 0 (enolate mediated) coupling process. This enantiomer has also been converted into a key intermediate which provides a route to the enantiomers of both macroline and alstonerine following the previous work of LeQuesne.
