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Barbosa, José Diomedes; Oliveira, Mariana Correia; Oliveira, Carlos Magno Chaves; Bomjardim, Henrique Dos Anjos; Ferreira, Tatiane Teles Albernaz; Duarte, Marcos Dutra; da Silveira, José Alcides Sarmento; Silveira, Natália da Silva E Silva; Barbosa, Camila Cordeiro; da Silva, Aluízio Otávio Almeida; Armién, Anibal; Brito, Marilene de Farias
Veterinary sciences, 11/2023, Letnik: 10, Številka: 12Journal Article
Melanomas are tumors arising from externally uncontrolled melanocytes that produce varying amounts of melanin. In this study, we report a case of melanoma with neurological impairment without evidence of cutaneous neoplastic lesions in an adult buffalo in the state of Pará, Brazil. Clinically, the buffalo exhibited apathy, decreased mandibular tone, and occasionally an open mouth with motor incoordination, and eventually succumbed to the condition. Necropsy revealed multifocal tumor masses in the brain, pituitary gland, trigeminal ganglion, and spinal cord. The neoplastic cells showed strong positive signals for vimentin, Melan-A, PNL-2, and SOX10. The diagnosis was made via necropsy, histopathology, and positive immunostaining for Melan-A and PNL-2, which are specific markers for melanocyte identification.
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