E-viri
Recenzirano
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Ikezoe, Takayuki; Takeuchi, Asako; Isaka, Mayuka; Arakawa, Yu; Iwabu, Naomi; Kin, Tsukie; Anabuki, Kazuki; Sakai, Mizu; Taniguchi, Ayuko; Togitani, Kazuto; Yokoyama, Akihito
Leukemia research, 11/2012, Letnik: 36, Številka: 11Journal Article
Abstract We treated individuals for disseminated intravascular coagulation (DIC) caused by acute promyelocytic leukemia (APL) ( n = 9) using human soluble thrombomodulin (rTM) in combination with all- trans retinoic acid (ATRA) and chemotherapy, and compared the clinical outcomes with historical control patients ( n = 8) treated with ATRA and/or chemotherapy. Two control patients developed intracranial vascular incidents. On the other hand, no bleeding related mortality was noted in rTM-treated patients. Notably, treatment with rTM rescued patients from DIC earlier than historical controls (log rank test, p = 0.019). These results suggest that administration of rTM should be considered for the treatment of individuals with DIC associated with APL.
