E-viri
Recenzirano
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Bink, Anna; Kucharíková, Soňa; Neirinck, Bram; Vleugels, Jef; Van Dijck, Patrick; Cammue, Bruno P. A.; Thevissen, Karin
The Journal of infectious diseases, 12/2012, Letnik: 206, Številka: 11Journal Article
In this study, we demonstrated that in vitro Candida albicans biofilms grown in the presence of didofenac showed increased susceptibility to caspofungin. These findings were further confirmed using a catheterassociated biofilm model in rats. C. albicans-inoculated catheters retrieved from rats that were treated with both didofenac and caspofungin contained significantly fewer biofilm cells and showed no visible biofilms inside the catheter lumens, as documented by scanning electron microscopy, as compared to catheters retrieved from rats receiving only caspofungin or didofenac. This report indicates that didofenac could be useful in combination therapy with caspofungin to treat C. albicans biofilm-associated infections.
