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  • Effects of Actissist, a dig...
    Bucci, Sandra; Berry, Natalie; Ainsworth, John; Berry, Katherine; Edge, Dawn; Eisner, Emily; Emsley, Richard; Forbes, Gordon; Hassan, Lamiece; Lewis, Shôn; Machin, Matthew; Haddock, Gillian

    Psychiatry research, 09/2024, Letnik: 339
    Journal Article

    •Actissist is a cognitive behaviour therapy informed smartphone app for psychosis.•ClinTouch is a symptom monitoring app for psychosis.•In a powered RCT, Actissist did not improve psychotic symptoms more than clintouch.•Both groups showed improvement across all clinical measures. Both apps were safe.•Early psychosis patients should be given a choice of using digital symptom monitoring or digital intervention tools as part of routine care. Schizophrenia affects 24 million people worldwide. Digital health interventions drawing on psychological principles have been developed, but their effectiveness remains unclear. This parallel, assessor-blinded, randomized clinical trial aimed to investigate whether a cognitive behaviour therapy-informed digital health intervention (Actissist app) confers added benefit on psychotic symptoms over and above remote symptom monitoring (ClinTouch app). Participants recruited from UK community health services were randomized 1:1 to receive either Actissist plus treatment as usual (TAU) or ClinTouch plus TAU. Eligible participants were adults with schizophrenia-spectrum psychosis within five years of first episode onset meeting a criterion level of positive symptoms severity. The primary outcome was Positive and Negative Syndrome Scale (PANSS) symptoms total score at 12 weeks post-randomization. Intention-to-treat analysis included 172 participants, with 149 participants (86.6 %) providing primary outcome data. Actissist plus TAU was not associated with greater reduction than an active control remote symptom monitoring app (ClinTouch) in PANSS total score at post-randomization. There were no significant effects between groups across secondary measures. There were no serious adverse reactions. Both groups improved on the primary psychotic symptoms measure at primary end-point and on secondary measures over time. The Actissist app is safe but not superior to digital symptom monitoring.